Targeted genetic clearance of P21-POSITIVE cells
1 paper3 findings
- 1 lab in 1 country
- Funders: Deutsche Forschungsgemeinschaft and 8 more
- Animals1
Outcomes
3Age-related bone loss
no changein animals1
1 study
Age-related bone loss
no changein animals1
Targeted genetic clearance of P21-POSITIVE cells have no effect on age-related bone loss.
“By contrast, p21+ cell clearance did not alter bone loss due to aging”
Animalsagingbone
The Journal of clinical investigation16 May 2024
Senescence-associated signatures
downin animals1
1 study
Senescence-associated signatures
downin animals1
Targeted genetic clearance of P21-POSITIVE cells decrease senescence-associated signatures.
“Targeted genetic clearance of p21+ cells suppressed senescence-associated signatures within the fracture callus and accelerated fracture healing.”
Animalsfollowing fracturefracture callus
The Journal of clinical investigation16 May 2024
Fracture healing
upin animals1
1 study
Fracture healing
upin animals1
Targeted genetic clearance of P21-POSITIVE cells improve fracture healing.
“Targeted genetic clearance of p21+ cells suppressed senescence-associated signatures within the fracture callus and accelerated fracture healing.”
Animalsfollowing fracturebone
The Journal of clinical investigation16 May 2024
Latest
The Journal of Clinical Investigation
Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair
Experiments in animalsCellular senescence