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Suppressed ketosis

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Human trial1

Outcomes

5

GLP-1

downin humans1

1 study

  1. Suppressed ketosis decreases GLP-1 in humans (2.40-fold (p = 0.0209)).

    “glucagon-like peptide-1 (GLP-1), 2.40-fold (p = 0.0209)”

    Human trial21 daysfemalesn = 10

    Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females

    Biomedicines12 Jul 2024

More on GLP-1

Leptin

upin humans1

1 study

  1. Suppressed ketosis increases leptin in humans (3.35-fold (p = 0.0010)).

    “leptin, 3.35-fold (p = 0.0010)”

    Human trial21 daysfemalesn = 10

    Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females

    Biomedicines12 Jul 2024

More on Leptin

Glucose

upin humans1

1 study

  1. Suppressed ketosis increases glucose in humans (1.17-fold (p = 0.0088)).

    “glucose, 1.17-fold (p = 0.0088)”

    Human trial21 daysfemalesn = 10

    Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females

    Biomedicines12 Jul 2024

More on Glucose

Insulin

upin humans1

1 study

  1. Suppressed ketosis increases insulin in humans (1.83-fold (p = 0.0006)).

    “Ketosis suppression significantly increased insulin, 1.83-fold (p = 0.0006)”

    Human trial21 daysfemalesn = 10

    Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females

    Biomedicines12 Jul 2024

More on Insulin

HOMA-IR

upin humans1

1 study

  1. Suppressed ketosis increases HOMA-IR in humans (2.13-fold (p = 0.0008)).

    “homeostasis model assessment for insulin resistance (HOMA-IR), 2.13-fold (p = 0.0008)”

    Human trial21 daysfemalesn = 10

    Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females

    Biomedicines12 Jul 2024

More on HOMA-IR

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