Substance abuse

1. Substance abuse is associated with epigenetic age in humans.

   “In covariate-adjusted regression models across different epigenetic age acceleration measures, group was significantly associated with AgeAccelGrim, and substance abuse was also a significant predictor.”

   HumansCovariate-adjusted regression modelsdorsolateral prefrontal cortex

   DNA methylation-derived age acceleration reveals neurodevelopmental and stress-linked pathways in depression and suicide

   Journal of affective disorders·27 Apr 2026

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