Structural racism

9 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 2 countries
1 finding against

Humans5

Associations

Subjective cognitive decline

upin humans2downin humans1

2 studies

Structural racism is associated with subjective cognitive decline in humans (aOR 1.15, 95% CI 1.07–1.24).
“versus Q1, Q2 had higher odds of SCD (aOR=1.15; 95%CI 1.07–1.24)”
Humanspooled analysis, vs Q1n = 180,790
State-Level Structural Racism and Subjective Cognitive Decline: Regional Variation in U.S. Adults
GSA 2025 abstract31 Dec 2025
Structural racism lowers the risk of subjective cognitive decline in humans.
“the risk of subjective cognitive decline decreased with increasing exposure to structural racism among Hispanic individuals.”
Humansamong Hispanic individuals
IMPACT OF STRUCTURAL RACISM ON COGNITIVE DECLINE
GSA 2024 abstract31 Dec 2024
Structural racism is associated with subjective cognitive decline in humans.
“Greater exposure to structural racism was associated with higher odds of reporting subjective cognitive decline.”
Humans
IMPACT OF STRUCTURAL RACISM ON COGNITIVE DECLINE
GSA 2024 abstract31 Dec 2024

Cardiovascular disease

upin humans1RR 1.21

1 study

Structural racism raises the risk of cardiovascular disease in humans (pooled RR 1.21 (95% CI 1.05–1.39)).
“Meta-analysis of five studies revealed a 21% increased risk of adverse cardiovascular outcomes with high structural racism exposure (pooled RR: 1.21; 95% CI: 1.05–1.39; Chi-square test = 98%).”
Review
Redlining, Segregation, and Disparities in Heart Health: Structural Racism as a Driver of Adverse Cardiovascular Outcomes
AHA Scientific Sessions 2025 abstract3 Nov 2025