Soft food

1. Soft food induces cellular senescence in rats.

   “Reduced loads impaired distally localized compression-stimulated PIEZO1 and mesially localized tension-stimulated TRPV4, decreased mitochondrial function (MFN2), and increased cell senescence in mesial and distal periodontal regions.”

   Animalsperiodontium4 wkmales

   Chewing-Activated TRPV4/PIEZO1-HIF-1α-Zn Axes in a Rat Periodontal Complex

   Journal of dental research·Jan 28, 2025

More on Cellular senescence

1. Soft food decreases MFN2 in rats.

   “Reduced loads impaired distally localized compression-stimulated PIEZO1 and mesially localized tension-stimulated TRPV4, decreased mitochondrial function (MFN2), and increased cell senescence in mesial and distal periodontal regions.”

   Animalsperiodontium4 wkmales

   Chewing-Activated TRPV4/PIEZO1-HIF-1α-Zn Axes in a Rat Periodontal Complex

   Journal of dental research·Jan 28, 2025

More on MFN2

1. Soft food increases cementum volume fraction in rats.

   “Significant changes in alveolar socket and root shapes with decreased periodontal ligament space and increased cementum volume fraction were observed in maxillae on reduced loads (soft food).”

   Animalscementum4 wkmales

   Chewing-Activated TRPV4/PIEZO1-HIF-1α-Zn Axes in a Rat Periodontal Complex

   Journal of dental research·Jan 28, 2025

1. Soft food decreases periodontal ligament space in rats.

   “Significant changes in alveolar socket and root shapes with decreased periodontal ligament space and increased cementum volume fraction were observed in maxillae on reduced loads (soft food).”

   Animalsperiodontal ligament4 wkmales

   Chewing-Activated TRPV4/PIEZO1-HIF-1α-Zn Axes in a Rat Periodontal Complex

   Journal of dental research·Jan 28, 2025

1. Soft food extends lifespan in mice (19 weeks maximum lifespan).

   “Survival past weaning revealed a number of CS-like symptoms including small size, progressive loss of adiposity, and neurological symptoms, with a maximum lifespan of 19 weeks.”

   Animalsin Csa(-/-) | Xpa(-/-) mice fed soft food

   Lifespan extension by dietary intervention in a mouse model of Cockayne syndrome uncouples early postnatal development from segmental progeria

   Aging cell·Sep 11, 2013

1. Soft food improves survival past weaning in mice.

   “providing mutant pups with soft food from as late as postnatal day 14 allowed survival past weaning with high penetrance”

   Animalsin Csa(-/-) | Xpa(-/-) mutant pups

   Lifespan extension by dietary intervention in a mouse model of Cockayne syndrome uncouples early postnatal development from segmental progeria

   Aging cell·Sep 11, 2013