SN-2 palmitate
1 paper5 findings
In SAMP8 mice over eight weeks, SN-2 palmitate improves cognition, increases NAD+ metabolism and mitochondrial biogenesis, and reduces hippocampal inflammation and senescence. All five findings come from one lab without independent replication; the Food Science Institute Foundation funds the work, and all have an author affiliated with Meiji.
Findings from 1 paper from September 2026
- 1 lab in 1 country
- Funder: Food Science Institute Foundation
- 5 of 5 findings with company ties
- Animals1
Outcomes
5Mitochondrial biogenesis (PGC-1α)
upin mice1
1 study
Mitochondrial biogenesis (PGC-1α)
upin mice1
SN-2 palmitate increases mitochondrial biogenesis (PGC-1α) in mice.
“accompanied by upregulation of mitochondrial biogenesis-related factors (PGC-1α, NRF1, TFAM).”
AnimalsSAMP88 weeks
The Journal of nutritional biochemistry3 Sep 2026
NAD+ metabolism
upin mice1
1 study
NAD+ metabolism
upin mice1
SN-2 palmitate increases NAD+ metabolism in mice.
“sn-2 palmitate enhanced NAD+/NADH ratio and increased Sirt1/3 deacetylase activities”
AnimalsSAMP88 weeks
The Journal of nutritional biochemistry3 Sep 2026
Inflammation
downin mice1
1 study
Inflammation
downin mice1
SN-2 palmitate decreases inflammation in mice.
“reduced hippocampal expression of senescence markers (p16, p21) and pro-inflammatory cytokines (IL-6, TNF-α).”
AnimalsSAMP8hippocampus8 weeks
The Journal of nutritional biochemistry3 Sep 2026
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
SN-2 palmitate decreases cellular senescence in mice.
“reduced hippocampal expression of senescence markers (p16, p21)”
AnimalsSAMP8hippocampus8 weeks
The Journal of nutritional biochemistry3 Sep 2026
Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
SN-2 palmitate improves cognitive function in mice.
“sn-2 palmitate-enriched lipid supplementation significantly improved cognitive performance”
AnimalsSAMP88 weeks
The Journal of nutritional biochemistry3 Sep 2026