Sesamol
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- 3 of 3 findings with company ties
- Animals1
Outcomes
3Inflammation
downin mice1
1 study
Inflammation
downin mice1
Sesamol decreases inflammation in mice.
“suppression of oxidative stress (ROS, MDA, SOD), inflammatory factors (IL-6, TNFα) and cell cycle inhibitors (p53, p21, p16)”
Animalsin aged obese mice and H2O2-treated 3T3-L1 adipocytesadipose tissue
Plant foods for human nutrition (Dordrecht, Netherlands)16 Dec 2024
Oxidative stress and ROS signalling
downin mice1
1 study
Oxidative stress and ROS signalling
downin mice1
Sesamol decreases oxidative stress and ROS signalling in mice.
“Notably, the presence of sesamol showed marked activation of Nrf2 and inhibition of p-p38MAPK, along with the suppression of oxidative stress (ROS, MDA, SOD)”
Animalsin aged obese mice and H2O2-treated 3T3-L1 adipocytesadipose tissue
Plant foods for human nutrition (Dordrecht, Netherlands)16 Dec 2024
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
Sesamol decreases cellular senescence in mice.
“sesamol, acted as an activator of Nrf2 and exerted negative impacts on the activation of p38MAPK, which were associated with amelioration of adipose senescence”
Animalsin aged obese mice and H2O2-treated 3T3-L1 adipocytesadipose tissue
Plant foods for human nutrition (Dordrecht, Netherlands)16 Dec 2024
Latest
Plant Foods for Human Nutrition
Ameliorating Oxidative Stress-Aggravated Adipose Tissue Senescence by Sesamol in Aged Obese Mice via Nrf2/p38MAPK Signaling
Experiments in miceInterventions