Senescence-associated exosomes
Senescence-associated exosomes has been studied in 1 paper since 2023: none in people yet, 1 in cells. No study of it in people or animals has been published yet. The newest paper, Feb 23, 2023: “Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells”.
1 paper studies it3 findingsUpdated
- 1 lab in 1 country
- Funders: Brown University and 1 more
- Cells1
What did studies of Senescence-associated exosomes find?
3Studies of Senescence-associated exosomes measured 3 outcomes; the most studied are TGF-β signaling (1 study), Ki-67 (1) and alpha-smooth muscle actin (1).
TGF-β signaling
upin cells1
1 study
TGF-β signaling
upin cells1
Senescence-associated exosomes activate TGF-β signaling in cells.
“We revealed SA-EXOs possess unique miRNA content that influence myofibroblast phenotypes via TGF-β pathway activation.”
Cellsin normal MSCsbone marrow-derived mesenchymal stem cells
Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells
Aging
Ki-67
upin cells1
1 study
Ki-67
upin cells1
Senescence-associated exosomes increase Ki-67 in cells.
“elevated both alpha smooth muscle actin (protein increased in senescent, activated cells) and Ki-67 (proliferative marker) expression in SA-EXO treated MSCs compared to untreated MSCs.”
Cellsin normal MSCsbone marrow-derived mesenchymal stem cells
Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells
Aging
Alpha-smooth muscle actin
upin cells1
1 study
Alpha-smooth muscle actin
upin cells1
Senescence-associated exosomes increase alpha-smooth muscle actin in cells.
“These modulated genes related to TGF-β pathway and elevated both alpha smooth muscle actin (protein increased in senescent, activated cells) and Ki-67 (proliferative marker) expression in SA-EXO treated MSCs”
Cellsin normal MSCsbone marrow-derived mesenchymal stem cells
Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells
Aging