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Semsns

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

3

Cellular senescence

downin human cells1

1 study

  1. Semsns decrease cellular senescence in human cells.

    “SeMSNs effectively reduce oxidative stress and downregulate senescence markers (p16, p21), suppressing senescence in both naturally aged primary mouse embryonic fibroblasts (MEFs) and H2O2-induced HEK-293T cells.”

    Cellsin H2O2-induced HEK-293T cells

    Enhanced Selenium Supplement Extends Lifespan and Delays Multi-Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)2 Oct 2025

More on Cellular senescence

Frailty

downin mice1

1 study

  1. Semsns decrease frailty in mice.

    “In aged mice, SeMSNs extend lifespan, reduce frailty, and improve age-related conditions, including muscle atrophy, renal dysfunction, cognitive decline, and hepatic steatosis, while restoring metabolic balance.”

    Animalsin aged mice

    Enhanced Selenium Supplement Extends Lifespan and Delays Multi-Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)2 Oct 2025

Lifespan

upin mice1

1 study

  1. Semsns extend lifespan in mice.

    “In aged mice, SeMSNs extend lifespan, reduce frailty, and improve age-related conditions, including muscle atrophy, renal dysfunction, cognitive decline, and hepatic steatosis, while restoring metabolic balance.”

    Animalsin aged mice

    Enhanced Selenium Supplement Extends Lifespan and Delays Multi-Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)2 Oct 2025

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