Salubrinal
- 1 lab in 1 country
- Funders: National Heart, Lung, and Blood Institute and 1 more
- Humans1
Outcomes
2Col1a1 expression
downin human cells1
1 study
Col1a1 expression
downin human cells1
Salubrinal decreases Col1a1 expression in human cells.
“salubrinal inhibited COL1A1 but not p21 expression in MG132-treated fibroblasts.”
Cellsin MG132-treated fibroblastslung fibroblast
Endoplasmic reticulum stress-induced senescence in human lung fibroblasts
American journal of physiology. Lung cellular and molecular physiology21 May 2024
CDKN1A expression
downin human cells1
1 study
CDKN1A expression
downin human cells1
Salubrinal decreases CDKN1A expression in human cells.
“Finally, the ER stress inhibitor salubrinal decreased the expression of p21 compared to vehicle and MG132 treatments”
Cellscompared to vehicle and MG132 treatmentslung fibroblast
Endoplasmic reticulum stress-induced senescence in human lung fibroblasts
American journal of physiology. Lung cellular and molecular physiology21 May 2024
Latest
American Journal of Physiology Lung Cellular and Molecular Physiology
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Experiments in cellsMechanisms
American Journal of Physiology Lung Cellular and Molecular Physiology
Endoplasmic reticulum stress-induced senescence in human lung fibroblasts
Study in peopleER unfolded protein response