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Resistomycin

Intervention

1 paper2 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

2

Chronic obstructive pulmonary disease progression

downin mice1

1 study

  1. Resistomycin decreases chronic obstructive pulmonary disease progression in mice.

    “which accelerates the ubiquitin-dependent degradation of p21 and consequently inhibits lung cellular senescence and COPD progression.”

    AnimalsCOPD modellung

    Inhibition of E3 ligase Pellino-1 attenuates chronic obstructive pulmonary disease and lung cellular senescence by promoting p21 degradation

    PreprintJun 29, 2022

More on Chronic obstructive pulmonary disease progression

lung cellular senescence

downin mouse cells1

1 study

  1. Resistomycin decreases lung cellular senescence in mouse cells.

    “Resistomycin, a potential Pellino-1 inhibitor, interrupts the interaction between Pellino-1 and p21, which accelerates the ubiquitin-dependent degradation of p21 and consequently inhibits lung cellular senescence”

    Cellslung

    Inhibition of E3 ligase Pellino-1 attenuates chronic obstructive pulmonary disease and lung cellular senescence by promoting p21 degradation

    PreprintJun 29, 2022

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