AgingResearch.NewsJoin free

Rapid weight loss protocol

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Human trial1

Outcomes

4

IPF GL and IPF GL BP scores

upin humans1

1 study

  1. Rapid weight loss protocol increases IPF GL and IPF GL BP scores in humans.

    “the RWL group showed a significant post-intervention increase in IPF GL (p = 0.015) and IPF GL BP scores (p = 0.017).”

    Human trialtrained powerlifters; post-intervention versus pre-intervention4 days followed by 2-hour recoverymalesn = 13

    Making weight makes sense: relative performance gains after rapid weight loss in powerlifting: a randomized controlled trial

    Journal of the International Society of Sports Nutrition27 Aug 2025

More on IPF GL and IPF GL BP scores

Maximal strength

no changein humans1

1 study

  1. Rapid weight loss protocol has no effect on maximal strength in humans.

    “no significant differences in maximal strength (SQ, BP, DL, TOTAL) were observed between C1 and C2 or between groups.”

    Human trialtrained powerlifters4 days followed by 2-hour recoverymalesn = 26

    Making weight makes sense: relative performance gains after rapid weight loss in powerlifting: a randomized controlled trial

    Journal of the International Society of Sports Nutrition27 Aug 2025

Fat mass, fat-free mass, and body water

downin humans1

1 study

  1. Rapid weight loss protocol decreases fat mass, fat-free mass, and body water in humans (Fat mass -15.7%; fat-free mass -2.36%; body water -2.41%).

    “significant decreases in fat mass (-15.7%), fat-free mass (-2.36%), and body water (-2.41%) compared to CON (all p < 0.01)”

    Human trialtrained powerlifters; compared with habitual diet and hydration4 daysmalesn = 13

    Making weight makes sense: relative performance gains after rapid weight loss in powerlifting: a randomized controlled trial

    Journal of the International Society of Sports Nutrition27 Aug 2025

Body mass

downin humans1−4.8%

1 study

  1. Rapid weight loss protocol decreases body mass in humans (-4.81%).

    “The RWL group achieved a mean body mass reduction of 4.81%”

    Human trialtrained powerlifters4 daysmalesn = 13

    Making weight makes sense: relative performance gains after rapid weight loss in powerlifting: a randomized controlled trial

    Journal of the International Society of Sports Nutrition27 Aug 2025

Latest

Related