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R159

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development and 4 more
  • Animals1

Outcomes

5

Physical activity

upin mice1

1 study

  1. R159 increases physical activity in mice.

    “R159 reduced weight gain induced by HFD and increased physical activity levels.”

    Animalshigh-fat diet

    Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet

    Scientific reports28 Dec 2024

Weight gain

downin mice1

1 study

  1. R159 decreases weight gain in mice.

    “R159 reduced weight gain induced by HFD”

    Animalshigh-fat diet

    Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet

    Scientific reports28 Dec 2024

Neurogenesis

upin mice1

1 study

  1. R159 increases neurogenesis in mice.

    “R159 was protective against trabecular bone and articular cartilage loss and markedly prevented neurogenesis decline.”

    Animalshigh-fat diet-induced multimorbidity

    Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet

    Scientific reports28 Dec 2024

Trabecular bone and articular cartilage loss

downin mice1

1 study

  1. R159 protects against trabecular bone and articular cartilage loss in mice.

    “R159 was protective against trabecular bone and articular cartilage loss”

    Animalshigh-fat diet-induced multimorbiditytrabecular bone and articular cartilage

    Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet

    Scientific reports28 Dec 2024

Systemic inflammatory responses

downin mice1

1 study

  1. R159 decreases systemic inflammatory responses in mice.

    “R159 significantly decreased systemic inflammatory responses in adipose tissue and liver.”

    Animalshigh-fat diet-induced chronic inflammationadipose tissue and liver

    Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet

    Scientific reports28 Dec 2024

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