Qing-luo-yin

1. Qing-luo-yin decreases inflammation in rat cells.

   “reduced the secretion of IL-1β, IL-6 and TNF-α in the monocytes cultured with the corresponding medium.”

   Cellsin monocytes cultured with conditioned medium

   Qing-Luo-Yin-induced SIRT1 inhibition contributes to the immune improvement of adjuvant-induced arthritis rats

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 17, 2024Preprint

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1. Qing-luo-yin decreases NAMPT in rat cells.

   “eNAMPT decrease was especially notable, which was obviously weakened by SIRT1 overexpression but overshadowed SIRT1-silencing.”

   Cellsin pre-adipocytes

   Qing-Luo-Yin-induced SIRT1 inhibition contributes to the immune improvement of adjuvant-induced arthritis rats

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 17, 2024Preprint

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1. Qing-luo-yin inhibits SIRT1 in rats.

   “inhibited the expression and function of SIRT1, causing concomitant changes of related signals and adipkines production.”

   Animalsin AIA ratsliver and adipose tissues38 days

   Qing-Luo-Yin-induced SIRT1 inhibition contributes to the immune improvement of adjuvant-induced arthritis rats

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 17, 2024Preprint

More on SIRT1

1. Qing-luo-yin decreases joint injuries in rats.

   “QLY didn’t further improve immune milieu in AIA rats, but greatly eased paw edema and joint injuries.”

   Animalsin AIA rats38 days

   Qing-Luo-Yin-induced SIRT1 inhibition contributes to the immune improvement of adjuvant-induced arthritis rats

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 17, 2024Preprint

1. Qing-luo-yin inhibits NF-κB signalling in rat cells.

   “The medium from the compounds-treated pre-adipocytes impaired NF-κB activation in AIA serum-cultured monocytes.”

   Cellsin AIA serum-cultured monocytes

   Qing-Luo-Yin Eased Adjuvant-Induced Arthritis by Inhibiting SIRT1-Controlled Visfatin Production in White Adipose Tissues

   Journal of inflammation research·Sep 1, 2024

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1. Qing-luo-yin decreases visfatin in rats (from 191.8 to 127.0 pg/mL).

   “visfatin was obviously reduced in QLY-treated AIA rats' blood (from 191.8 to 127.0 pg/mL).”

   Animalsin adjuvant-induced arthritisblood38 days

   Qing-Luo-Yin Eased Adjuvant-Induced Arthritis by Inhibiting SIRT1-Controlled Visfatin Production in White Adipose Tissues

   Journal of inflammation research·Sep 1, 2024

More on Visfatin

1. Qing-luo-yin decreases adjuvant-induced arthritis in rats.

   “QLY attenuated all these abnormalities and joint injuries.”

   Animalsin adjuvant-induced arthritis38 days

   Qing-Luo-Yin Eased Adjuvant-Induced Arthritis by Inhibiting SIRT1-Controlled Visfatin Production in White Adipose Tissues

   Journal of inflammation research·Sep 1, 2024

More on Adjuvant-induced arthritis