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Ptupb

Intervention

1 paper4 findings

PubChem 52951990ChEBI 233137

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

4

Autophagy

upin mouse cells1

1 study

  1. Ptupb activates autophagy in mouse cells.

    “PTUPB enhanced hepatocyte autophagy by inhibiting the PI3K/AKT/mTOR pathway through Sirt1, contributing to the suppression of senescence.”

    Cellsin AML12 cells

    COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR

    International journal of molecular sciences27 Jul 2022

More on Autophagy

Senescence-associated beta-galactosidase

downin mouse cells1

1 study

  1. Ptupb decreases senescence-associated beta-galactosidase in mouse cells.

    “PTUPB decreased the lipid content, the number of β-gal positive cells, and the expression of p53, p21, and γH2AX proteins in AML12 cells.”

    Cellsin PA-treated AML12 hepatocytes

    COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR

    International journal of molecular sciences27 Jul 2022

More on Senescence-associated beta-galactosidase

Cellular senescence

downin mice1

1 study

  1. Ptupb decreases cellular senescence in mice.

    “PTUPB significantly reduced the expression of liver senescence-related molecules p16, p53, and p21 in HFD mice.”

    Animalsin HFD-induced NAFLD miceliver

    COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR

    International journal of molecular sciences27 Jul 2022

More on Cellular senescence

Liver injury

downin mice1

1 study

  1. Ptupb decreases liver injury in mice.

    “PTUPB alleviated liver injury, decreased collagen and lipid accumulation, restored glucose tolerance, and reduced hepatic triglyceride levels in HFD-induced NAFLD mice.”

    Animalsin HFD-induced NAFLD miceliver

    COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR

    International journal of molecular sciences27 Jul 2022

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