PS1

1. PS1 decreases oxidative stress and ROS signaling in mouse cells.

   “This increase could be attributed to a reduction in ROS production and the activity of electron transport chain complex 1 (ETC C1) and Nox in Min6 cells by PS1.”

   Cellshigh glucosepancreatic beta cells

   Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice

   Cellular and molecular life sciences : CMLS·Mar 19, 2023

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1. PS1 decreases cell death in mice.

   “Accordingly, PS1 reduced cell death and dysfunction in the pancreatic β-islets of db/db mice”

   Animalsdb/db micepancreatic isletsn = 7

   Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice

   Cellular and molecular life sciences : CMLS·Mar 19, 2023

1. PS1 extends lifespan longevity in mice.

   “reversed diabetes in db/db mice, 6 to 7 mice per group, as evidenced by blood glucose, glycosylated hemoglobin A1c (HbA1c), glucose tolerance test, diabetic incidence, survival and longevity (P < 0.05 or less).”

   Animalsdb/db micen = 7

   Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice

   Cellular and molecular life sciences : CMLS·Mar 19, 2023

1. PS1 protects against diabetes in mice.

   “Furthermore, PS1 alone and in combination with metformin significantly reversed diabetes in db/db mice”

   Animalsdb/db micen = 7

   Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice

   Cellular and molecular life sciences : CMLS·Mar 19, 2023

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