Prostaglandin D2

  • 1 lab in 1 country
  • Funders: Korea Health Industry Development Institute and 3 more
  • Cells1

Outcomes

5

Progression to morula and blastocyst stages

upin cells1

1 study
  1. Prostaglandin D2 improves progression to morula and blastocyst stages in cells.

    “PGD2 enhanced mitochondrial membrane potential, accelerated cleavage kinetics, and improved progression to the morula and blastocyst stages.”

    Cellsembryo

    Prostaglandin D2 reinforces mitochondrial quality control to enhance ovarian and embryonic competence

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie23 May 2026

Estradiol and progesterone secretion

upin cells1

1 study
  1. Prostaglandin D2 increases estradiol and progesterone secretion in cells.

    “PGD2 promoted steroidogenic activation, evidenced by increased StAR and CYP11A1 expression and significantly elevated estradiol and progesterone secretion.”

    Cellsovarian cells

    Prostaglandin D2 reinforces mitochondrial quality control to enhance ovarian and embryonic competence

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie23 May 2026

Mitochondrial membrane potential

upin cells1

1 study
  1. Prostaglandin D2 increases mitochondrial membrane potential in cells.

    “Structural and functional analyses demonstrated restoration of mitochondrial network integrity, increased mitochondrial membrane potential (ΔΨm), elevated basal respiration, spare respiratory capacity, and ATP production”

    Cellsovarian cells

    Prostaglandin D2 reinforces mitochondrial quality control to enhance ovarian and embryonic competence

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie23 May 2026

More on Mitochondrial membrane potential

Senescence-associated beta-galactosidase

downin cells1

1 study
  1. Prostaglandin D2 decreases senescence-associated beta-galactosidase in cells.

    “PGD2 significantly enhanced cellular viability and attenuated senescence-associated β-galactosidase activity.”

    Cellsovarian cells

    Prostaglandin D2 reinforces mitochondrial quality control to enhance ovarian and embryonic competence

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie23 May 2026

More on Senescence-associated beta-galactosidase

Cell viability

upin cells1

1 study
  1. Prostaglandin D2 increases cell viability in cells.

    “PGD2 significantly enhanced cellular viability and attenuated senescence-associated β-galactosidase activity.”

    Cellsovarian cells

    Prostaglandin D2 reinforces mitochondrial quality control to enhance ovarian and embryonic competence

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie23 May 2026

Latest

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