Polysialic acid
1 paper4 findings
- 1 lab in 1 country
- Animals1
Outcomes
4Synapse
downin mice1
1 study
Synapse
downin mice1
Polysialic acid protects against synapse in mice.
“cognitive improvements correlated with the normalized size of CD68 + microglial lysosomes and reduced amounts of pre- and postsynaptic proteins at these structures.”
Animals
Short Polysialic Acid Counteracts Age-Related Synaptic and Cognitive Deficits
bioRxiv (Cold Spring Harbor Laboratory)13 Mar 2025Preprint
Inflammation
no changein mice1
1 study
Inflammation
no changein mice1
Polysialic acid has no effect on inflammation in mice.
“did not affect neuronal structure (MAP2 levels), expression of senescence (lipofuscin) or neuroinflammation (microglial Iba1) markers”
Animalshippocampus5 days
Short Polysialic Acid Counteracts Age-Related Synaptic and Cognitive Deficits
bioRxiv (Cold Spring Harbor Laboratory)13 Mar 2025Preprint
Cellular senescence
no changein mice1
1 study
Cellular senescence
no changein mice1
Polysialic acid has no effect on cellular senescence in mice.
“Five-day treatment with NANA12 did not affect neuronal structure (MAP2 levels), expression of senescence (lipofuscin) or neuroinflammation (microglial Iba1) markers”
Animalshippocampus5 days
Short Polysialic Acid Counteracts Age-Related Synaptic and Cognitive Deficits
bioRxiv (Cold Spring Harbor Laboratory)13 Mar 2025Preprint
Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
Polysialic acid improves cognitive function in mice.
“Strikingly, NANA12 promoted cognitive flexibility in attentional set-shifting (ASST) tests and spatial memory in the Barnes maze in very old mice.”
Animals
Short Polysialic Acid Counteracts Age-Related Synaptic and Cognitive Deficits
bioRxiv (Cold Spring Harbor Laboratory)13 Mar 2025Preprint