Pnaktide

1. Pnaktide decreases liver fibrosis in mice (p<0.01).

   “and exercise with a paucity of apoptotic activity, mitigation of cell senescence, and regression of liver fibrosis (p<0.01).”

   Animalsdiet-induced NASH modelliver

   Normalization of the α1-Na/K-ATPase/Src Signalosome Restored Microbiota Communities and Rescinded NASH Progression in the Mouse

   Preprints.org·May 25, 2022Preprint

1. Pnaktide decreases cellular senescence in mice (p<0.05).

   “and those changes were associated with a decrease in liver inflammation and senescence”

   Animalsdiet-induced NASH modelliver24 weeks

   Normalization of the α1-Na/K-ATPase/Src Signalosome Restored Microbiota Communities and Rescinded NASH Progression in the Mouse

   Preprints.org·May 25, 2022Preprint

More on Cellular senescence

1. Pnaktide decreases inflammation in mice (p<0.05).

   “and those changes were associated with a decrease in liver inflammation and senescence”

   Animalsdiet-induced NASH modelliver24 weeks

   Normalization of the α1-Na/K-ATPase/Src Signalosome Restored Microbiota Communities and Rescinded NASH Progression in the Mouse

   Preprints.org·May 25, 2022Preprint

More on Inflammation

1. Pnaktide improves microbiome composition in mice.

   “Microbiota community changes regressed to their wild-type state at 24 weeks on treated animals”

   Animalsdiet-induced NASH modelterminal ileum

   Normalization of the α1-Na/K-ATPase/Src Signalosome Restored Microbiota Communities and Rescinded NASH Progression in the Mouse

   Preprints.org·May 25, 2022Preprint

More on Microbiome composition