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Platelet-derived growth factor ab/bb

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Emory University and 2 more
  • Cells1

Outcomes

3

Cell cycle regulation gene expression

upin human cells1

1 study

  1. Platelet-derived growth factor ab/bb increases cell cycle regulation gene expression in human cells.

    “In both NP and AF cells, rhPDGF-AB/BB treatment upregulated genes involved in cell cycle regulation”

    Cellsderived from degenerated intervertebral discsrecombinant humannucleus pulposus and annulus fibrosus cells5 d

    Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

    eLife16 Jul 2025

More on Cell cycle regulation gene expression

PDGFRA expression

upin human cells1

1 study

  1. Platelet-derived growth factor ab/bb increases PDGFRA expression in human cells.

    “However, rhPDGF-AB/BB treatment increased PDGFRA expression”

    Cellsirradiation-induced senescencerecombinant humannucleus pulposus cell

    Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

    eLife16 Jul 2025

More on PDGFRA expression

Cellular senescence

downin human cells1

1 study

  1. Platelet-derived growth factor ab/bb decreases cellular senescence in human cells.

    “rhPDGF-AB/BB treatment increased PDGFRA expression and mitigated the senescence progression through increased cell population in the S phase, reduced SA-β-Gal activity”

    Cellsirradiation-induced senescencerecombinant humannucleus pulposus cell

    Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

    eLife16 Jul 2025

More on Cellular senescence

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