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Plant-based caloric restriction diet

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Human trial1

Outcomes

3

Blood urea nitrogen

upin humans1

1 study

  1. Plant-based caloric restriction diet increases blood urea nitrogen in humans.

    “while increasing BUN compared to CRD (all Pbetween-group<0.05).”

    Human trialcompared to CRD in obese participants12-weekn = 52

    Metabolic Benefits of Plant-Based Caloric Restriction Diets in Obesity Management—A Twelve-Week Randomized Controlled Trial

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on Blood urea nitrogen

Uric acid

downin humans1

1 study

  1. Plant-based caloric restriction diet decreases uric acid in humans.

    “PB-CRD significantly reduced total body fat percentage (−2.96% vs. −0.81%), UA levels, and SOD activity while increasing BUN compared to CRD (all Pbetween-group<0.05).”

    Human trialcompared to CRD in obese participants12-weekn = 52

    Metabolic Benefits of Plant-Based Caloric Restriction Diets in Obesity Management—A Twelve-Week Randomized Controlled Trial

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on Uric acid

Body fat percentage

downin humans1

1 study

  1. Plant-based caloric restriction diet decreases body fat percentage in humans (−2.96% vs. −0.81%).

    “PB-CRD significantly reduced total body fat percentage (−2.96% vs. −0.81%)”

    Human trialcompared to CRD in obese participants12-weekn = 52

    Metabolic Benefits of Plant-Based Caloric Restriction Diets in Obesity Management—A Twelve-Week Randomized Controlled Trial

    ADA Scientific Sessions 2025 abstract13 Jun 2025

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