AgingResearch.NewsJoin free

Physioxia

Intervention

2 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

  • 2 independent labs in 2 countries
  • 1 finding against
  • Funders: Centres de Recerca de Catalunya and others
  • Cells2

Outcomes

5

Cellular senescence

upin cells1downin human cells1

2 studies

  1. Physioxia increases cellular senescence in cells.

    “In contrast, under physiological conditions, neurons treated with cisplatin exhibited senescence marker expression”

    Cellsunder cisplatin exposure (1 μg/mL) compared to supraphysiological normoxia1 μg/mL

    Oxygen matters: Unraveling the role of oxygen in the neuronal response to cisplatin

    Journal of the peripheral nervous system : JPNSSep 27, 2024

  2. Physioxia decreases cellular senescence in human cells.

    “release of the pro-senescent factor IGFBP3 and β-galactosidase staining were lower in physioxic hiPSCs.”

    Cellsphysioxic vs hyperoxic culture

    Physioxia rewires mitochondrial complex composition to protect stem cell viability

    Redox biologySep 11, 2024

More on Cellular senescence

Inflammation

downin cells1

1 study

  1. Physioxia decreases inflammation in cells.

    “In contrast, under physiological conditions, neurons treated with cisplatin exhibited senescence marker expression and an attenuated inflammatory secretome.”

    Cellsunder cisplatin exposure (1 μg/mL) compared to supraphysiological normoxia1 μg/mL

    Oxygen matters: Unraveling the role of oxygen in the neuronal response to cisplatin

    Journal of the peripheral nervous system : JPNSSep 27, 2024

More on Inflammation

Mortality

downin cells1

1 study

  1. Physioxia decreases mortality in cells.

    “sensory neurons cultured under supraphysiological normoxic conditions show higher mortality”

    Cellsunder cisplatin exposure (1 μg/mL) compared to supraphysiological normoxia1 μg/mL

    Oxygen matters: Unraveling the role of oxygen in the neuronal response to cisplatin

    Journal of the peripheral nervous system : JPNSSep 27, 2024

Oxidative phosphorylation

downin human cells1

1 study

  1. Physioxia decreases oxidative phosphorylation in human cells.

    “physioxic hiPSCs revealed lower polarized mitochondrial membrane potential, altered mitochondrial network appearance and reduced basal respiration and electron transfer capacity.”

    Cellsphysioxic vs hyperoxic culture

    Physioxia rewires mitochondrial complex composition to protect stem cell viability

    Redox biologySep 11, 2024

More on Oxidative phosphorylation

Pathological karyotypes

downin human cells1

1 study

  1. Physioxia decreases pathological karyotypes in human cells (6 % vs. 32 % mosaicism).

    “physioxic -cultured hiPSC clones exhibited less pathological karyotypes than hyperoxic (e.g. 6 % vs. 32 % mosaicism)”

    Cellsphysioxic vs hyperoxic culture

    Physioxia rewires mitochondrial complex composition to protect stem cell viability

    Redox biologySep 11, 2024

Latest

Related