Phenylacetate

1 paper2 findings

1 lab in 1 country

Funders: British Heart Foundation and others

Animals1

Outcomes

1

Cellular senescence

upin mice1

1 study

Phenylacetate induces cellular senescence in mice.
“Here, we show that PAA promotes vascular niche senescence and perivascular adipose tissue (PVAT) dysfunction”
Animalsvascular niche
Gut Microbiota Production of Phenylacetate Programs Vascular Niche Senescence and Drives Atherosclerosis
bioRxiv (Cold Spring Harbor Laboratory)2 Mar 2026Preprint

More on Cellular senescence

Associations

1

Atherosclerosis

upin mice1

1 study

Phenylacetate raises the risk of atherosclerosis in mice.
“PAA administration to atherosclerosis-prone mice was sufficient to drive atherosclerosis without altering lipid profile.”
Animalsadministration to atherosclerosis-prone mice
Gut Microbiota Production of Phenylacetate Programs Vascular Niche Senescence and Drives Atherosclerosis
bioRxiv (Cold Spring Harbor Laboratory)2 Mar 2026Preprint

More on Atherosclerosis

Latest

2 in 12 months

bioRxiv2 Mar

Gut Microbiota Production of Phenylacetate Programs Vascular Niche Senescence and Drives Atherosclerosis

Preprint: experiments in miceCellular senescence

AHA Scientific Sessions 2025 Abstract3 Nov

Intestinal Microbiota-derived Phenylacetic acid Accelerates Perivascular Adipose Tissue Senescence and Atherosclerosis in Aging

Experiments in miceMicrobiome composition

Nature Aging13 May

Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging

Experiments in animalsMechanisms

Journal of Pharmaceutical and Biomedical Analysis11 May

Metabolomics study by metabolite profiling analysis in kidney and liver of calorie-restricted aging rats using GC-MS/MS

Experiments in animalsInterventions

Nature Aging11 Jan

Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence

Study in peopleMechanisms