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Phenyl n-tert-butylnitrone

Intervention

3 papers6 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 4 independent labs in 3 countries
  • Funder: Narodowe Centrum Nauki
  • Animals3

Outcomes

4

Lifespan

upin mice2upin rats1

3 studies

  1. Phenyl n-tert-butylnitrone extends lifespan in rats.

    “PBN-treated rats displayed prolonged mean life spans”

    Animalsin malignant stroke-prone spontaneously hypertensive ratsdrinking water

    Effect of radical scavenger N-tert-butyl-alpha-phenylnitrone on stroke in a rat model using a telemetric system

    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques1 Jan 2008

  2. Phenyl n-tert-butylnitrone extends lifespan in mice.

    “PBN-treated animals as compared with control animals had prolonged mean and maximum life spans.”

    Animals

    A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice

    Bioscience, biotechnology, and biochemistry1 Apr 1998

  3. Phenyl n-tert-butylnitrone extends lifespan in mice (56 weeks vs 42 weeks for 50% mean survival rate).

    “Overall, a 50% mean survival rate was found of 42 weeks for control as compared to 56 weeks for the PBN administered groups.”

    Animalsintraperitoneal injection

    The spin-trap N-tert-alpha-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse

    Biochemical and biophysical research communications26 Jun 1995

Cellular senescence

downin human cells1

1 study

  1. Phenyl n-tert-butylnitrone decreases cellular senescence in human cells.

    “When HT serum-treated ECs were pre-incubated with the ROS scavenger PBN, the activity of SA-β-Gal decreased.”

    CellsHT serum-treated ECs

    The TGF-β1-oxidative stress axis underlies accelerated senescence of endothelial cells exposed to serum from hypertensive patients

    Mechanisms of ageing and development26 Nov 2025

More on Cellular senescence

Body weight

no changein mice1

1 study

  1. Phenyl n-tert-butylnitrone has no effect on body weight in mice.

    “no significant change was found in their body weights”

    Animals

    A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice

    Bioscience, biotechnology, and biochemistry1 Apr 1998

More on Body weight

Water consumption

downin mice1

1 study

  1. Phenyl n-tert-butylnitrone decreases water consumption in mice.

    “Their water consumption decreased”

    Animals

    A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice

    Bioscience, biotechnology, and biochemistry1 Apr 1998

More on Water consumption

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