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PF-429242

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Basic and Applied Basic Research Foundation of Guangdong Province and 3 more
  • Animals1

Outcomes

1

Cellular senescence

downin mice1

1 study

  1. PF-429242 decreases cellular senescence in mice.

    “Notably, Urolithin A (UA) and the S1P inhibitor, PF429242, were found to alleviate astrocyte senescence and promote neuronal regeneration”

    Animalsin astrocyte-specific HSP60 knockout mice

    Astrocytic HSP60 Deletion Induced Astrocyte Senescence and Inhibited Neuroregeneration via Modulating the S1P/Truncated-BDNF Pathway

    Journal of neuroscience research31 May 2025

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