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Pevonedistat

Intervention

1 paper4 findings

PubChem 16720766ChEBI 145535MeSH C539933

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Beijing Nova Program and 1 more
  • Cells1

Outcomes

4

PI3K–AKT signalling

downin cells1

1 study

  1. Pevonedistat inhibits PI3K–AKT signalling in cells.

    “We confirmed that MLN4924 inhibits AKT phosphorylation, thereby suppressing its activation and further inhibits GSK-3β phosphorylation.”

    Cellsin macrophages

    MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype

    Lipids in health and disease2 Oct 2025

More on PI3K–AKT signalling

Foam cell formation

downin cells1

1 study

  1. Pevonedistat inhibits foam cell formation in cells.

    “These findings demonstrate that MLN4924 could inhibit the formation of foam cells”

    Cellsin macrophages

    MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype

    Lipids in health and disease2 Oct 2025

Autophagy

upin cells1

1 study

  1. Pevonedistat increases autophagy in cells.

    “The mechanism by which MLN4924 exerts these effects likely involves enhancing autophagy”

    Cellsin macrophages

    MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype

    Lipids in health and disease2 Oct 2025

More on Autophagy

Cellular senescence

downin cells1

1 study

  1. Pevonedistat decreases cellular senescence in cells.

    “MLN4924 inhibits macrophage senescence and suppresses the expressions of SASP factors.”

    Cellsin macrophages

    MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype

    Lipids in health and disease2 Oct 2025

More on Cellular senescence

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