PBI-4050

1. PBI-4050 inhibits TGF-β signalling in mice.

   “PBI-4050 inhibited kidney macrophage infiltration, oxidative stress, and TGF-β-mediated fibrotic signaling pathways, and it also protected against the development of tubulointerstitial fibrosis.”

   Animalskidney

   Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control

   JCI insight·17 May 2018

More on TGF-β signalling

1. PBI-4050 increases autophagy in mice.

   “In addition, PBI-4050 preserved (early treatment) or restored (late treatment) blood insulin levels and increased autophagy in islets.”

   Animalsislets

   Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control

   JCI insight·17 May 2018

More on Autophagy

1. PBI-4050 protects against diabetic nephropathy in mice.

   “Both early and late PBI-4050 treatment protected against progression of DN, as indicated by reduced histological glomerular injury and albuminuria”

   Animalsin eNOS-/- db/db mice

   Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control

   JCI insight·17 May 2018

More on Diabetic nephropathy

1. PBI-4050 extends lifespan in mice.

   “PBI-4050 treatment led to significant improvements in lifespan in the diabetic mice.”

   Animalsin diabetic mice

   Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control

   JCI insight·17 May 2018