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Parthenolide + S63845

Intervention

1 paper2 findings

PubChemPubChemChEBIChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Medical University of Lodz
  • Cells1

Outcomes

2

MCL1

downin human cells1

1 study

  1. Parthenolide + S63845 decreases MCL1 in human cells.

    “parthenolide combined with S63845 reduces the protein level of MCL-1”

    Cellsin melanoma cells

    Synergistic activity of S63845 and parthenolide to overcome acquired resistance to MEK1/2 inhibitor in melanoma cells: Mechanisms and therapeutic potential

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieMay 26, 2025

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Apoptosis

upin human cells1

1 study

  1. Parthenolide + S63845 induces apoptosis in human cells.

    “Parthenolide and S63845 synergize to cause massive apoptosis regardless of melanoma cell phenotypes”

    Cellsin melanoma cells regardless of phenotypes

    Synergistic activity of S63845 and parthenolide to overcome acquired resistance to MEK1/2 inhibitor in melanoma cells: Mechanisms and therapeutic potential

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieMay 26, 2025

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