Paederoside

1. Paederoside decreases IGF1R in human cells.

   “PSG, promotes targeted degradation of IGF1R through the ubiquitin-proteasome system.”

   Cells

   Paederoside Promotes Longevity and Fitness in C. elegans Through Ubiquitination and Degradation of DAF-2/IGF1R, Activating DAF-16/FOXO and SKN-1/NRF2 Transcription Factors

   International journal of molecular sciences·27 Feb 2026

More on IGF1R

1. Paederoside increases skn-1 in worms.

   “PSG treatment significantly up-regulated the expression of key antioxidant gene skn-1 and longevity-associated gene daf-16.”

   Model organismsunder conditions of oxidative stress

   Paederoside Promotes Longevity and Fitness in C. elegans Through Ubiquitination and Degradation of DAF-2/IGF1R, Activating DAF-16/FOXO and SKN-1/NRF2 Transcription Factors

   International journal of molecular sciences·27 Feb 2026

More on skn-1

1. Paederoside decreases lipofuscin in worms.

   “administration of 100 μg/mL PSG significantly reduced the accumulation of lipofuscin.”

   Model organisms100 μg/mL

   Paederoside Promotes Longevity and Fitness in C. elegans Through Ubiquitination and Degradation of DAF-2/IGF1R, Activating DAF-16/FOXO and SKN-1/NRF2 Transcription Factors

   International journal of molecular sciences·27 Feb 2026

More on Lipofuscin

1. Paederoside extends lifespan in worms.

   “We found that 50, 80, and 100 μg/mL of PSG could prolong the lifespan of C. elegans”

   Model organisms50, 80, and 100 μg/mL

   Paederoside Promotes Longevity and Fitness in C. elegans Through Ubiquitination and Degradation of DAF-2/IGF1R, Activating DAF-16/FOXO and SKN-1/NRF2 Transcription Factors

   International journal of molecular sciences·27 Feb 2026