P,p'-dde

4 papers11 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Humans3
Animals1

Outcomes

Cognitive function

downin humans2

2 studies

P,p'-dde impairs cognitive function in humans (β = −0.0221).
“Higher prenatal DDE was also associated with lower midlife Wechsler Digit Symbol Substitution Task score ( β = −0.0221).”
Humans
Association of pesticide exposure with plasma Aβ‐42/40 Ratio: Translational evidence from 5xFAD mice and the Child Health and Development Studies
AAIC 2025 abstract9 Jan 2026
P,p'-dde impairs cognitive function in humans (β = -0.020, CI = -0.037 to -0.003, p = 0.02).
“For the DSST, prenatal p ,p'‐DDE levels were associated with worse performance (β = ‐0.020, CI = ‐0.037 to ‐0.003, p = 0.02).”
Humansprenatal p,p'-DDE levelsn = 179
Association of prenatal pesticide exposure with plasma Aβ 42/40 and cognitive function in midlife: evidence from the Child Health and Development Studies
AAIC 2025 abstract23 Dec 2025

Aβ42/Aβ40 ratio

downin humans1downin mice1−31%

2 studies

P,p'-dde decreases Aβ42/Aβ40 ratio in mice (-31%).
“Serum Aβ‐42/40 was significantly reduced by 31% in DDE‐exposed mice”
Animalsin 5xFAD mice90 daysmales
Association of pesticide exposure with plasma Aβ‐42/40 Ratio: Translational evidence from 5xFAD mice and the Child Health and Development Studies
AAIC 2025 abstract9 Jan 2026
P,p'-dde decreases Aβ42/Aβ40 ratio in humans (β = -0.37, CI=-0.70 to -0.03, p = 0.03).
“Prenatal p ,p‐DDE (log‐transformed) levels were associated with lower plasma Aβ 42/40 in mid‐life (β = ‐0.37, CI=‐0.70 to ‐0.03, p = 0.03).”
Humansprenatal p,p'-DDE levels (log-transformed)plasman = 179
Association of prenatal pesticide exposure with plasma Aβ 42/40 and cognitive function in midlife: evidence from the Child Health and Development Studies
AAIC 2025 abstract23 Dec 2025

Associations

Low Aβ42/Aβ40 ratio

upin humans1

1 study

P,p'-dde raises the risk of low Aβ42/Aβ40 ratio in humans.
“the Odds Ratio for estimating lower Aβ‐42/40 was 2.6 and 3.2 for DDE tertiles 2 and 3, respectively. The test for trend across DDE tertiles was significant ( p = 0.04).”
Humans
Association of pesticide exposure with plasma Aβ‐42/40 Ratio: Translational evidence from 5xFAD mice and the Child Health and Development Studies
AAIC 2025 abstract9 Jan 2026

Fatty acid β-oxidation

upin humans1

1 study

P,p'-dde is associated with fatty acid β-oxidation in humans.
“Multiple metabolic pathways involved in fatty acid metabolism were associated with p,p’ ‐DDE, including the carnitine shuttle, fatty acid biosynthesis, and arachidonic acid, prostaglandin, and glycerophospholipid metabolism.”
Humansserumn = 362
Metabolome Wide Association Study of Serum DDE in Midlife Adults: Relevance to Prodromal ADRD
AAIC 2025 abstract24 Dec 2025