Oxymatrine

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Natural Science Foundation of China

Animals1

Outcomes

Foam cell formation

downin mouse cells1

1 study

Oxymatrine prevents foam cell formation in mouse cells.
“Consequently, this process delays macrophage senescence-induced foam cell formation”
Cellsvia delaying macrophage senescence
Oxymatrine Alleviates Atherosclerosis by Regulating Macrophage Senescence via the SIRT1-P53 Signaling Pathway
Phytotherapy research : PTR20 Jan 2026

SIRT1

upin mouse cells1

1 study

Oxymatrine activates SIRT1 in mouse cells.
“OMT directly binds to SIRT1 and stabilizes its protein.”
Cells
Oxymatrine Alleviates Atherosclerosis by Regulating Macrophage Senescence via the SIRT1-P53 Signaling Pathway
Phytotherapy research : PTR20 Jan 2026

Latest

1 in 12 months

Phytotherapy Research20 Jan

Oxymatrine Alleviates Atherosclerosis by Regulating Macrophage Senescence via the SIRT1-P53 Signaling Pathway

Experiments in miceAtherosclerosis

Paper

Oxymatrine

Outcomes

Latest

Oxymatrine Alleviates Atherosclerosis by Regulating Macrophage Senescence via the SIRT1-P53 Signaling Pathway

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