Oscillatory shear stress

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab

Funders: National Natural Science Foundation of China and 2 more

Animals1

Outcomes

4

HMOX1

upin human cells1

1 study

Oscillatory shear stress increases HMOX1 in human cells.
“It displayed increased expression following OSS treatment and co-expression with ERS-genes.”
Cellsunder oscillatory shear stress
Oscillatory shear stress mediates endothelial cell senescence by regulating endoplasmic reticulum stress through HMOX1
Cellular signalling25 Nov 2025

ER unfolded protein response

upin human cells1

1 study

Oscillatory shear stress activates ER unfolded protein response in human cells.
“Transcriptomic analysis (GSE276195) showed that OSS activated ERS”
Cellsin endothelial cells
Oscillatory shear stress mediates endothelial cell senescence by regulating endoplasmic reticulum stress through HMOX1
Cellular signalling25 Nov 2025

More on ER unfolded protein response

Cellular senescence

upin human cells1

1 study

Oscillatory shear stress induces cellular senescence in human cells.
“OSS induced senescence in ECs by increasing SA-β-gal staining levels and upregulating p53, p21, and p16 levels, as well as the senescence-associated secretory phenotype (SASP).”
Cellsin endothelial cells
Oscillatory shear stress mediates endothelial cell senescence by regulating endoplasmic reticulum stress through HMOX1
Cellular signalling25 Nov 2025

More on Cellular senescence

Inflammation

upin reviews1

1 study

Oscillatory shear stress induces inflammation.
“disturbed flow with low and oscillatory shear stress (OS), induces the athero-susceptible signaling network to activate glycolysis and inflammation in ECs”
Review
Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development
Journal of biomedical science1 Sep 2025

More on Inflammation

Latest

1 in 12 months

Cellular Signalling28 Nov

Oscillatory shear stress mediates endothelial cell senescence by regulating endoplasmic reticulum stress through HMOX1

Experiments in animalsER unfolded protein response

Journal of Biomedical Science2 Sep

Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development

ReviewAmino acid metabolism