Optimism

4 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Humans4

Associations

Cognitive function

upin humans1

1 study

Optimism is associated with cognitive function in humans.
“Higher optimism level was associated with better cognitive function and better self-rated memory”
Humans
Wellbeing Trajectories and Dementia Risk Among Mexican-Origin Adults Living in the U.S.
GSA 2025 abstract31 Dec 2025

Dementia

downin humans1HR 0.82

1 study

Optimism lowers the risk of dementia in humans (HR 0.82, 95% CI 0.79–0.85).
“a 1-standard deviation increase in optimism was associated with a lower hazard of developing dementia (hazard ratio = 0.82, 95% confidence interval 0.79–0.85)”
Humanscognitively healthy at baselineup to 14 yearsn = 9,071
Optimism and the Risk of Developing Dementia
GSA 2025 abstract31 Dec 2025