Oncolytic viruses

1. Oncolytic viruses activate cGAS–STING signalling in humans.

   “oncolytic viruses (OVs) selectively infect tumor cells, induce immunogenic cell death (ICD), and activate the cGAS-STING pathway”

   Reviewin tumor cells

   Oncolytic virus therapy in the elderly: immune frailty, challenges, and perspectives

   Frontiers in immunology·8 Oct 2025

More on cGAS–STING signalling

1. Oncolytic viruses increase objective response rate in humans (26.4-32.9%).

   “promising outcomes have been reported in melanoma/sarcoma subgroups, including objective response rates of 26.4-32.9%”

   Reviewmelanoma/sarcoma subgroups

   Oncolytic virus therapy in the elderly: immune frailty, challenges, and perspectives

   Frontiers in immunology·8 Oct 2025