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Oltipraz

Intervention

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1
  • Cells1

Outcomes

3

Muscle function

upin mice1

1 study

  1. Oltipraz improves muscle function in mice.

    “Nrf2 activator (Oltipraz) supplementation alleviates muscle atrophy and dysfunction induced by heat exposure”

    Animalsheat exposure

    Heat exposure promotes sarcopenia via gut microbiota-derived metabolites

    Aging cellOct 29, 2024

Deterioration of intercellular junctions

downin human cells1

1 study

  1. Oltipraz prevents deterioration of intercellular junctions in human cells.

    “Oltipraz significantly reduces cellular senescence and prevents the deterioration of intercellular junctions in HUVECs subjected to high glucose concentrations (25 mM).”

    Cellsunder high glucose concentrations (25 mM)endothelial cells25 mM glucose

    NRF2-HIF2α Signaling Attenuates Endothelial Cell Senescence and Maintains Intercellular Junctions in Diabetes

    International journal of biological sciencesJul 22, 2024

Cellular senescence

downin human cells1

1 study

  1. Oltipraz decreases cellular senescence in human cells.

    “Oltipraz significantly reduces cellular senescence and prevents the deterioration of intercellular junctions in HUVECs subjected to high glucose concentrations (25 mM).”

    Cellsunder high glucose concentrations (25 mM)endothelial cells25 mM glucose

    NRF2-HIF2α Signaling Attenuates Endothelial Cell Senescence and Maintains Intercellular Junctions in Diabetes

    International journal of biological sciencesJul 22, 2024

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