Obstructive sleep apnea

4 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 2 countries

Funders: National Institute on Aging and 4 more

Humans3

Outcomes

Functional connectivity

upin humans1

1 study

Obstructive sleep apnea increases functional connectivity in humans.
“There was also a trend showing higher FC in CS‐OSA compared to CS‐nonOSA.”
Humansprior to AD-related cognitive impairment (cognitively stable)
Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea
AAIC 2025 abstract23 Dec 2025

Associations

Stable hearing loss

upin humans1

1 study

Obstructive sleep apnea raises the risk of stable hearing loss in humans (RRR 1.79 (95% CI, 1.32-2.42)).
“with a higher likelihood of being in the stable hearing loss group (relative risk ratio = 1.79 [95% CI, 1.32-2.42])”
Humans8 yearsn = 1,433
Obstructive sleep apnea and functional hearing loss over 8 years: results from the National Health and Aging Trends Study
American journal of epidemiology13 Jan 2026