APOE 4 modifies the association between sleep apnea, inflammation, and tau pathology in older women

Abstract

Background: Obstructive sleep apnea (OSA) is thought to elevate Alzheimer's disease (AD) risk, possibly through an inflammatory mechanism. This may be particularly relevant for older women, who are underdiagnosed for OSA, express higher inflammatory responses and accumulate greater pathological tau in early AD stages than older men.