Navitoclax nanoparticles
1 paper3 findings
- 1 lab in 1 country
- Funders: Fundação para a Ciência e a Tecnologia and 1 more
- Animals1
Outcomes
3Exploratory behavior
upin rats1
1 study
Exploratory behavior
upin rats1
Navitoclax nanoparticles improve exploratory behavior in rats.
“Notably, only the NPs were able to reduce the presence of p21+ and p16+ BECs in vivo and enhance exploratory behavior.”
Animalschronologically aged rats
Nanoparticles as an efficient strategy to eliminate senescent brain endothelial cells
Journal of controlled release : official journal of the Controlled Release Society13 Jul 2026
Cellular senescence
downin rats1
1 study
Cellular senescence
downin rats1
Navitoclax nanoparticles decrease cellular senescence in rats.
“Notably, only the NPs were able to reduce the presence of p21+ and p16+ BECs in vivo and enhance exploratory behavior.”
Animalschronologically aged rats
Nanoparticles as an efficient strategy to eliminate senescent brain endothelial cells
Journal of controlled release : official journal of the Controlled Release Society13 Jul 2026
Blood-brain barrier permeability
downin rats1
1 study
Blood-brain barrier permeability
downin rats1
Navitoclax nanoparticles decrease blood-brain barrier permeability in rats.
“NPs successfully restored BBB integrity by reducing permeability, diminishing the burden of senescent BECs, and partially improving rat exploratory performance.”
Animalschronologically aged rats
Nanoparticles as an efficient strategy to eliminate senescent brain endothelial cells
Journal of controlled release : official journal of the Controlled Release Society13 Jul 2026