NAD+ depletion

NAD+ depletion has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Oct 22, 2026: “A metabolic molecule regulates cell recycling in brain neurons”.

Exposure

1 paper studies it2 findingsUpdated Oct 22, 2026

None of its findings points the other way.

1 lab in 1 country

Funders: Ministry of Health and Welfare, Republic of Korea and 1 more

Animals1

What did studies of NAD+ depletion find?

Studies of NAD+ depletion measured 2 outcomes; the most studied are lysosomal activity (1 study) and cilium length (1).

Lysosomal activity

downin mouse cells1

1 study

NAD+ depletion decreases lysosomal activity in mouse cells.
“NAD+ depletion induces ciliary shortening and diminishes lysosomal activity in a cilia-dependent manner.”
Cellscilia-dependenthypothalamic neuron
A metabolic molecule regulates cell recycling in brain neurons
Aging cellOct 22, 2026

Cilium length

downin mouse cells1

1 study

NAD+ depletion decreases cilium length in mouse cells.
“NAD+ depletion induces ciliary shortening and diminishes lysosomal activity in a cilia-dependent manner.”
Cellshypothalamic neuron
A metabolic molecule regulates cell recycling in brain neurons
Aging cellOct 22, 2026

Latest

1 paper in 12 months

Aging CellOct 22

A metabolic molecule regulates cell recycling in brain neurons

Experiments in hypothalamic neurons found that reducing a key metabolic molecule shortened hair-like cell projections and reduced activity in cellular recycling…Experiments in hypothalamic neurons found that reducing a key metabolic molecule shortened hair-like cell projections and reduced activity in cellular recycling compartments.

Animal cell studyNAD+ metabolism

Paper

NAD+ depletion

What did studies of NAD+ depletion find?

Latest

A metabolic molecule regulates cell recycling in brain neurons

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