N-3 polyunsaturated fatty acids

1. N-3 polyunsaturated fatty acids decrease tumour weight in mice (-42% (p = 0.02)).

   “weight by 42% (p = 0.02) compared to mice fed n-6 PUFA.”

   Animals20 weeksfemales

   Diets Rich in n-6 or n-3 Polyunsaturated Fatty Acids Combined with Exercise Influences Tumour Development in a Her-2 Breast Cancer Model

   Nutrients·10 Jul 2026

1. N-3 polyunsaturated fatty acids decrease tumour volume in mice (-55% (p < 0.001)).

   “Mice consuming n-3 PUFA had reduced tumour volume by 55% (p < 0.001)”

   Animals20 weeksfemales

   Diets Rich in n-6 or n-3 Polyunsaturated Fatty Acids Combined with Exercise Influences Tumour Development in a Her-2 Breast Cancer Model

   Nutrients·10 Jul 2026

1. N-3 polyunsaturated fatty acids decrease NCOA4 in mouse cells.

   “n-3 PUFAs downregulated NCOA4 expression by inactiviting the LGR5/β-catenin signaling pathway.”

   Cellsin IVD cellsintervertebral disc

   n-3 polyunsaturated fatty acids delay intervertebral disc degeneration by inhibiting nuclear receptor coactivator 4-mediated iron overload

   iScience·13 Dec 2023

More on NCOA4

1. N-3 polyunsaturated fatty acids inhibit cellular senescence in mice.

   “the optimized composition of PUFAs in the TG mice had a significant impact on delaying IVDD and cellular senescence of intervertebral disc (IVD).”

   Animalsin fat-1 transgenic mice with IVDDintervertebral discmales

   n-3 polyunsaturated fatty acids delay intervertebral disc degeneration by inhibiting nuclear receptor coactivator 4-mediated iron overload

   iScience·13 Dec 2023

More on Cellular senescence

1. N-3 polyunsaturated fatty acids protect against intervertebral disc degeneration in mice.

   “the optimized composition of PUFAs in the TG mice had a significant impact on delaying IVDD and cellular senescence of intervertebral disc (IVD).”

   Animalsin fat-1 transgenic mice with IVDDintervertebral discmales

   n-3 polyunsaturated fatty acids delay intervertebral disc degeneration by inhibiting nuclear receptor coactivator 4-mediated iron overload

   iScience·13 Dec 2023

More on Intervertebral disc degeneration