Murine cytomegalovirus
Murine cytomegalovirus has been studied in 3 papers since 2018: none in people yet, 3 in animals. The research so far is in animals. The newest paper, Oct 1, 2024: “Late-life Attenuation of Cytomegalovirus-mediated CD8 T Cell Memory Inflation: Shrinking of the Cytomegalovirus Latency Niche”.
3 papers study it3 findingsUpdated
- 1 lab in 1 country
- Funders: National Institute on Aging and 4 more
- Animals3
What did studies of Murine cytomegalovirus find?
3Studies of Murine cytomegalovirus measured 3 outcomes; the most studied are memory inflation (1 study), TCR repertoire diversity (1) and immune defense (1).
Memory inflation
upin mice1
1 study
Memory inflation
upin mice1
Murine cytomegalovirus increases memory inflation in mice.
“confirmed that MI magnitude was directly proportional to the infectious dose, reaching a setpoint by midlife”
Animals102, 104, and 106 PFU
Journal of immunology (Baltimore, Md. : 1950)
TCR repertoire diversity
upin mice1
1 study
TCR repertoire diversity
upin mice1
Murine cytomegalovirus increases TCR repertoire diversity in mice.
“old MCMV-infected mice recruited many diverse clonotypes that afforded broad and often more efficient recognition of antigenic peptide variants.”
AnimalsLm-OVA infection
Proceedings of the National Academy of Sciences of the United States of America
Immune defense
upin mice1
1 study
Immune defense
upin mice1
Murine cytomegalovirus improves immune defense in mice.
“Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection”
Animalsinfection with Listeria monocytogenes expressing OVA (Lm-OVA)
Proceedings of the National Academy of Sciences of the United States of America