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Heligmosomoides polygyrus

Intervention

3 papers study it4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funder: Agence Nationale de la Recherche
  • Animals3

Outcomes

4

Forced swim test

upin mice1

1 study

  1. Heligmosomoides polygyrus improves forced swim test in mice.

    “in mice infected with the nematode only, the greater M2 macrophage population resulted in better results in the forced swim test”

    Animalsin ageing C57BL/6 mice

    Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice

    International journal of molecular sciences

Neurodegeneration

upin mice1

1 study

  1. Heligmosomoides polygyrus increases neurodegeneration in mice.

    “intraperitoneal LPS-induced systemic inflammation resulting in brain neurodegeneration was enhanced by prolonged Heligmosomoides polygyrus infection in C57BL/6 mice”

    Animalsin LPS-treated ageing C57BL/6 micebrain

    Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice

    International journal of molecular sciences

Accentuated senescent phenotype

upin mice1

1 study

  1. Heligmosomoides polygyrus increases accentuated senescent phenotype in mice.

    “mice exposed to the nematode had an accentuated senescent phenotype.”

    Animalsearly life infection

    Early life infection and host senescence

    Experimental gerontology

Lifespan

downin mice1

1 study

  1. Heligmosomoides polygyrus shortens lifespan in mice.

    “both treatments (H. polygyrus infection and LPS challenge) reduced longevity.”

    Animalsearly life infection

    Early life infection and host senescence

    Experimental gerontology

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