TCR repertoire diversity

1. Exercise increases TCR repertoire diversity in humans.

   Human trialin Lynch syndrome carriersaerobic cycling52 weeks

   Exercise-associated epigenetic remodeling and TCR repertoire dynamics in Lynch syndrome carriers · iScience · 28 Aug 2026

Exercise →

1. Thymus transplantation decreases TCR repertoire diversity in mice.

   Animalsold RAG1-deficient thymus transplanted into athymic nude recipients compared to young transplantsold RAG1-deficient thymusthymus

   The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire · Aging cell · 21 Aug 2026

Thymus transplantation →

1. Thymus decreases TCR repertoire diversity in mice.

   Animalsin 18-month thymus compared to young thymusthymus

   The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire · Aging cell · 21 Aug 2026