Morus

1. Morus activates AMPK signaling.

   “MLE activated the AMPK/SIRT1/PGC-1α pathways, participated in mitochondrial biosynthesis and oxidative metabolism and delayed D-gal-induced aging”

   AnimalsD-galactose-induced aging in mice and L-02 cells

   Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro

   Journal of ethnopharmacology·Mar 23, 2023

More on AMPK signaling

1. Morus protects against oxidative stress and ROS signaling in mice.

   “protected against oxidative stress in mice and liver cells, in a dose-dependent manner, up-regulating T-SOD and T-AOC, while reducing ROS and MDA levels”

   AnimalsD-galactose-treated mice

   Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro

   Journal of ethnopharmacology·Mar 23, 2023

More on Oxidative stress and ROS signaling

1. Morus extends lifespan in worms.

   “MLE could significantly prolonged nematodes' average life span”

   Model organismsin C. elegans

   Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro

   Journal of ethnopharmacology·Mar 23, 2023