Mocetinostat

1. Mocetinostat has no effect on chondrocyte viability in human cells.

   “Mocetinostat, an HDAC inhibitor, selectively kills senescent TC28a2 cells and primary human knee chondrocytes via apoptosis while not affecting the viability of NSCs.”

   CellsNon-senescent cellsTC28a2 cells and primary human knee chondrocytes

   Class I histone deacetylases and their inhibitors as targets to modulate cellular senescence in osteoarthritis

   GeroScience·25 Apr 2026

1. Mocetinostat induces apoptosis in human cells.

   “Mocetinostat, an HDAC inhibitor, selectively kills senescent TC28a2 cells and primary human knee chondrocytes via apoptosis”

   CellsSenescent cellsTC28a2 cells and primary human knee chondrocytes

   Class I histone deacetylases and their inhibitors as targets to modulate cellular senescence in osteoarthritis

   GeroScience·25 Apr 2026

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