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MIR-449A mimetic

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 2 countries
  • Funders: European Commission and 4 more
  • 1 of 1 finding with company ties
  • Animals1

Outcomes

1

Cellular senescence

downin mouse cells1

1 study

  1. MIR-449A mimetic decreases cellular senescence in mouse cells.

    “miR-449a upregulation using mimetics reduces senescence, primarily through targeted reduction of p16Ink4a, p21Cip1, and the PI3K-mTOR signaling pathway.”

    Cellsmimetic

    microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling

    Proceedings of the National Academy of Sciences of the United States of America28 Mar 2023

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