Microglial depletion followed by endogenous repopulation

Microglial depletion followed by endogenous repopulation improves functional recovery.

“promoting functional recovery across preclinical models of acute injury, neurodegeneration, and demyelinating disease”

Reviewpreclinical models of acute injury, neurodegeneration, and demyelinating diseasecentral nervous system

Harnessing Microglial Repopulation: From Inflammatory Drivers to Therapeutic Allies in CNS Diseases

Glia·28 May 2026

Microglial depletion followed by endogenous repopulation increases phagocytic capacity.

“upregulated homeostatic and neurotrophic gene expression, and enhanced phagocytic capacity”

Reviewendogenous repopulation following transient microglial depletionmicroglia

Harnessing Microglial Repopulation: From Inflammatory Drivers to Therapeutic Allies in CNS Diseases

Glia·28 May 2026

Microglial depletion followed by endogenous repopulation decreases inflammatory profiles.

“Emerging evidence demonstrates that repopulated microglia exhibit a distinct phenotype-characterized by attenuated inflammatory profiles”

Reviewendogenous repopulation following transient microglial depletionmicroglia

Harnessing Microglial Repopulation: From Inflammatory Drivers to Therapeutic Allies in CNS Diseases

Glia·28 May 2026