Mets-ir
Mets-ir has been studied in 7 papers since 2024: 6 observational studies in people, 1 review; 4 in the past year. The newest paper, Jul 24, 2026: “Insulin Resistance Indices and Subclinical Left Ventricular Systolic Dysfunction in Adults: A Systematic Review and Meta-Analysis”.
7 papers study it5 findingsUpdated
At a glance
The findings reach people, from one lab or study. 3 independent labs in 1 country.
“the highest METS-IR level (Q4) was associated with increased all-cause (hazard ratio [HR] 1.38, 95% confidence interval [CI] 1.14-1.67)”
None of its findings points the other way.
- 3 independent labs in 1 country
- Funders: Natural Science Foundation of Shandong Province and 1 more
- Humans6
What is mets-ir linked with?
5Studies link mets-ir with 5 measures, among them Discrimination for cardiometabolic multimorbidity, cardiometabolic multimorbidity and mild cognitive impairment.
Discrimination for cardiometabolic multimorbidity
upin humans1
1 study
Discrimination for cardiometabolic multimorbidity
upin humans1
Mets-ir predicts discrimination for cardiometabolic multimorbidity in humans (ROC analysis, adjusted AUC) (adjusted AUC 0.685).
“METS-IR yielded the highest adjusted AUC (0.685), followed by TyG (AUC 0.664).”
HumansROC analysis, adjusted AUCn = 4,173
Frontiers in endocrinology
Cardiometabolic multimorbidity
upin humans1OR 6.79
1 study
Cardiometabolic multimorbidity
upin humans1OR 6.79
Mets-ir is linked with a higher risk of cardiometabolic multimorbidity in humans (fully adjusted model, fourth versus first quartile) (OR 6.79 (95% CI 4.85-9.52)).
“METS-IR showed the strongest risk gradient, with an OR of 6.79 (95% CI 4.85-9.52) comparing the fourth versus the first quartile.”
Humansfully adjusted model, fourth versus first quartilen = 4,173
Frontiers in endocrinology
Mild cognitive impairment
upin humans1
1 study
Mild cognitive impairment
upin humans1
Mets-ir is linked with a higher risk of mild cognitive impairment in humans (highest vs lowest quartile; individuals without diabetes) (1.50 (95% CI: 1.09, 2.06), highest vs lowest quartile).
“Logistic regression analysis revealed significant associations between these surrogate indices and MCI.”
Humanshighest vs lowest quartile; individuals without diabetes7-year follow-upn = 4,027
Lipids in health and disease
Cardiovascular disease mortality
upin humans1HR 1.52
1 study
Cardiovascular disease mortality
upin humans1HR 1.52
Mets-ir is linked with a higher risk of cardiovascular disease mortality in humans (highest vs lowest quartile (Q4 vs Q1)) (HR 1.52 (95% CI 1.10-2.12)).
“and CVD mortality (HR 1.52, 95% CI 1.10-2.12) compared with the Q1 level”
Humanshighest vs lowest quartile (Q4 vs Q1)
Diabetes, obesity & metabolism
Mortality
upin humans1HR 1.38
1 study
Mortality
upin humans1HR 1.38
Mets-ir is linked with a higher risk of mortality in humans (highest vs lowest quartile (Q4 vs Q1)) (HR 1.38 (95% CI 1.14-1.67)).
“the highest METS-IR level (Q4) was associated with increased all-cause (hazard ratio [HR] 1.38, 95% confidence interval [CI] 1.14-1.67)”
Humanshighest vs lowest quartile (Q4 vs Q1)
Diabetes, obesity & metabolism