Tyg-waist circumference

Tyg-waist circumference has been studied in 3 papers since 2025: 3 observational studies in people; 2 in the past year. The newest paper, Apr 7, 2026: “Comparing the associations of eight surrogate markers of insulin resistance with rapid decline in kidney function and the incidence of CKD in Chinese middle-aged and elderly non-diabetic population”.

Exposure

3 papers study it2 findingsUpdated

See all 3 papers on tyg-waist circumference

At a glance

The findings reach people, from one lab or study. 2 independent labs in 1 country.

“For each 1-standard deviation (SD) increase in TyG-WC, the risks of developing first, double, and triple CRM diseases increased by 51.4%, 88.6%, and 128.7%, respectively (all P < 0.001)”
Associations of six insulin resistance-related indices with the risk and progression of cardio-renal-metabolic multimorbidity: evidence from the UK biobankCardiovascular diabetology2025doi:10.1186/s12933-025-02928-w

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.
  • 2 independent labs in 1 country
  • Funders: Basic and Applied Basic Research Foundation of Guangdong Province and 5 more
  • Humans3

What is tyg-waist circumference linked with?

2

Studies link tyg-waist circumference with 2 measures: cardiometabolic disease and cardio-renal-metabolic multimorbidity.

Cardiometabolic disease

upin humans1

1 study
  1. Tyg-waist circumference is linked with a higher risk of cardiometabolic disease in humans (high index with low MVPA, compared with low index and high MVPA) (aHR 1.96 (95% CI 1.77-2.17)).

    “1.96 (95%CI: 1.77-2.17) for TyG-WC”

    Humanshigh index with low MVPA, compared with low index and high MVPA

    Joint association of different insulin resistance-related indices and moderate-to-vigorous physical activity with risk of cardiometabolic disease and multimorbidity: insights from the UK Biobank prospective cohort study

    Lipids in health and disease

More on Cardiometabolic disease

Cardio-renal-metabolic multimorbidity

upin humans1

1 study
  1. Tyg-waist circumference is linked with a higher risk of cardio-renal-metabolic multimorbidity in humans (per 1-SD increase; first, double and triple CRM diseases) (+51.4% risk of first CRM disease per 1-SD increase).

    “For each 1-standard deviation (SD) increase in TyG-WC, the risks of developing first, double, and triple CRM diseases increased by 51.4%, 88.6%, and 128.7%, respectively (all P < 0.001)”

    Humansper 1-SD increase; first, double and triple CRM diseases

    Associations of six insulin resistance-related indices with the risk and progression of cardio-renal-metabolic multimorbidity: evidence from the UK biobank

    Cardiovascular diabetology

More on Cardio-renal-metabolic multimorbidity

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 1May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 01 paper in 12 months