Ethylparaben

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Institute of Mental Health and Neurosciences

Humans1
Model organisms1

Outcomes

Oxidative damage

upin flies1

1 study

Ethylparaben increases oxidative damage in flies.
“and elevated oxidative damage (↑MDA, ↓FRAP) in a dose-dependent manner.”
Model organismsContinuous dietary exposure0.5–1.5%Throughout development and adulthood
Chronic Dietary Exposure to Methylparaben and Ethyl paraben Induces Developmental, Biochemical, and Behavioural Toxicity in Drosophila melanogaster
bioRxiv (Cold Spring Harbor Laboratory)15 Oct 2025Preprint

Locomotor performance

downin flies1

1 study

Ethylparaben impairs locomotor performance in flies.
“Both adult climbing and larval crawling performances were impaired, linking biochemical stress to neuromuscular dysfunction.”
Model organismsContinuous dietary exposure0.5–1.5%Throughout development and adulthood
Chronic Dietary Exposure to Methylparaben and Ethyl paraben Induces Developmental, Biochemical, and Behavioural Toxicity in Drosophila melanogaster
bioRxiv (Cold Spring Harbor Laboratory)15 Oct 2025Preprint